Study Design. Review and reinterpretation of existing literature. Objective. To suggest how
intervertebral disc degeneration might be distinguished from the physiologic processes of …

Intervertebral disc (IVD) degeneration is an often investigated pathophysiological condition
because of its implication in causing low back pain. As human material for such studies is …

Authored by experts of international renown, the new edition of The Biomechanics of Back
Pain forms a bridge between the latest research and the effective clinical management of …

Study Design. Range of motion, neutral zone, and stiffness parameters of the complete
cervical, thoracic, and lumbar sheep spine were determined in flexion and extension, axial …

Study Design. The authors performed a correlative macroscopic, histologic, and
immunohistochemical investigation on human lumbar intervertebral discs using complete …

Of the many problems associated with low back pain, those which are most amenable to
biomechanical investigation are identified. Recent advances in lumbar spinal mechanics are …

Study Design. In vivo study of the effect of injection of osteogenic protein-1 (OP-1) on a
rabbit anular needle puncture model of intervertebral disc (IVD) degeneration. Objective. To …

Study Design. A new recombinant adenoviral vector expressing Sox9, a chondrocyte-
specific transcription factor, was tested in a chondroblastic cell line and primary human …

Study Design. To characterize age-related changes in the matrix of human intervertebral
disc (IVD) specimens, human specimens from the third to the eighth decade of life were …

Study Design. A study of the disc height and biochemical changes in the rabbit intervertebral
disc after injection of osteogenic protein-1 into the nucleus pulposus. Objectives. To …