Newborn bloodspot screening (NBS) began in the early 1960s based on the work of Dr.
Robert “Bob” Guthrie in Buffalo, NY, USA. His development of a screening test for …

Abstract Background Globally, Sickle cell disease (SCD) is one of the most common genetic
disease with high childhood mortality. Early identification of babies with SCD through …

There is limited capacity and infrastructure in sub-Saharan Africa to conduct clinical trials for
the identification of efficient and effective new prevention, diagnostic and treatment …

Background Pregnancy presents a critical period for any maternal and child health
intervention that may impact the health of the newborn. With low antenatal care attendance …

Background: Sickle cell disease (SCD) is the single most important genetic cause of
childhood mortality globally. Newborn screening (NBS) is the recommended intervention …

Objectives Growing global human mobility raises concerns about impacts on global health,
particularly on the prevalence of sickle cell disease. This research unveiled the level of …

Background: Sickle cell disease is a major genetic disease with the greatest burden in sub-
Saharan Africa, of which Nigeria is the epicenter. Premarital genotype screening for sickle …

Abstract Sickle Cell Disease (SCD) is an inheritable genetic disease occurring worldwide.
Nigeria is regarded as the epicenter of the disease, with a high number of SCD babies born …

Abstract Background: Globally, Sickle cell disease (SCD) is one of the most common genetic
disease with high childhood mortality. Early identi cation of babies with SCD through …

The case fatality rate among children living with sickle cell disease was approximately 50%
to 90% in Sub-Saharan Africa. Though researchers have contributed social determinants of …