Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …

Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …

Despite nearly three decades of advances in the management of rheumatoid arthritis (RA), a
substantial minority of patients are exposed to multiple DMARDs without necessarily …

Since its discovery in 1975, TNFα has been a subject of intense study as it plays significant
roles in both immunity and cancer. Such attention is well deserved as TNFα is unique in its …

TNF is a pleiotropic cytokine with important functions in homeostasis and disease
pathogenesis. Recent discoveries have provided insights into TNF biology that introduce …

Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction.
Cytokines play a key role in its pathogenesis. They contribute to the induction and …

Rheumatoid arthritis (RA) is a chronic prototypic immune-mediated inflammatory disease
which is characterized by persistent synovial inflammation, leading to progressive joint …

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly affects
synovial joints. During the course of RA, the synovium transforms into hyperplastic invasive …

Objective To determine the role of gasdermin E (GSDME)–mediated pyroptosis in the
pathogenesis and progression of rheumatoid arthritis (RA), and to explore the potential of …