Work over the last decade has uncovered a new layer of epigenetic dysregulation. It is now
appreciated that somatic missense mutations in histones, the packaging agents of genomic …

Genetic and genomic techniques have proven incredibly powerful for identifying and
studying molecular players implicated in the epigenetic regulation of DNA-templated …

The identification of mechanisms to promote memory T (Tmem) cells has important
implications for vaccination and anti-cancer immunotherapy,,–. Using a CRISPR-based …

Interactions between biomolecules underlie all cellular processes and ultimately control cell
fate. Perturbation of native interactions through mutation, changes in expression levels or …

The nucleosome acidic patch is a major interaction hub for chromatin, providing a platform
for enzymes to dock and orient for nucleosome-targeted activities. To define the molecular …

Genes encoding histone proteins are recurrently mutated in tumor samples, and these
mutations may impact nucleosome stability, histone post-translational modification, or …

Epigenetics is the study of heritable molecular determinants that are independent of
phenotypic features. The epigenetic features include DNA methylation, histone …

Recent studies have identified serotonylation of glutamine-5 on histone H3 (H3Q5ser) as a
novel posttranslational modification (PTM) associated with active transcription. While …

Recent genomic data points to a growing role for somatic mutations altering core histone
and linker histone-encoding genes in cancer. However, the prevalence and the clinical and …

Nucleosomes represent hubs in chromatin organization and gene regulation and interact
with a plethora of chromatin factors through different modes. In addition, alterations in …