The discovery of the Klotho (KL) gene, which was originally identified as a putative aging-
suppressor gene, has generated tremendous interest and has advanced understanding of …

Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local
factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion …

Background Hyperphosphatemia has been identified in the past decade as a strong
predictor of mortality in advanced chronic kidney disease (CKD). For example, a study of …

FGF23 is a bone-derived hormone that regulates systemic phosphate homeostasis, vitamin
D metabolism and α-Klotho expression through a novel bone-kidney axis. FGF23 inhibits …

The discovery of fibroblast growth factor 23 (FGF-23) has expanded our understanding of
phosphate and vitamin D homeostasis and provided new insights into the pathogenesis of …

Elevations of circulating Fibroblast growth factor 23 (FGF23) are associated with adverse
cardiovascular outcomes and progression of renal failure in chronic kidney disease (CKD) …

Phosphorus retention occurs from higher dietary phosphorus intake relative to its renal
excretion or dialysis removal. In the gastrointestinal tract the naturally existing organic …

Background and objectives: Cardiovascular disease is the main cause of mortality in chronic
kidney disease (CKD) patients. Vitamin D might have beneficial effects on vascular health …

Background and objectives: The discovery of fibroblast growth factor-23 (FGF-23) and the
elucidation of its function as a phosphaturic and 1, 25 (OH) 2 VitD counter-regulatory …

The development of chronic kidney disease (CKD) is accompanied by a progressive
decrease in the ability to produce 1, 25-dihydroxyvitamin D. Pharmacological replacement …