Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
M DuPage, JA Bluestone - Nature Reviews Immunology, 2016 - nature.com
CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …
can also adapt their functions in response to changing circumstances. Although this …
The who's who of T‐cell differentiation: human memory T‐cell subsets
YD Mahnke, TM Brodie, F Sallusto… - European journal of …, 2013 - Wiley Online Library
Following antigen encounter and subsequent resolution of the immune response, a single
naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic …
naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic …
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division
MW Rudloff, P Zumbo, NR Favret, JJ Roetman… - Nature …, 2023 - nature.com
Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …
Network-based machine learning approach to predict immunotherapy response in cancer patients
Immune checkpoint inhibitors (ICIs) have substantially improved the survival of cancer
patients over the past several years. However, only a minority of patients respond to ICI …
patients over the past several years. However, only a minority of patients respond to ICI …
Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells
Recent technical developments have enabled the transcriptomes of hundreds of cells to be
assayed in an unbiased manner, opening up the possibility that new subpopulations of cells …
assayed in an unbiased manner, opening up the possibility that new subpopulations of cells …
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
W Liao, JX Lin, WJ Leonard - Immunity, 2013 - cell.com
Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …
Human nutrition, the gut microbiome and the immune system
Marked changes in socio-economic status, cultural traditions, population growth and
agriculture are affecting diets worldwide. Understanding how our diet and nutritional status …
agriculture are affecting diets worldwide. Understanding how our diet and nutritional status …
Regulation and function of mTOR signalling in T cell fate decisions
H Chi - Nature reviews immunology, 2012 - nature.com
The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell
growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR …
growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR …
IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation
W Liao, JX Lin, WJ Leonard - Current opinion in immunology, 2011 - Elsevier
Interleukin-2 (IL-2) is a pleiotropic cytokine that drives T-cell growth, augments NK cytolytic
activity, induces the differentiation of regulatory T cells, and mediates activation-induced cell …
activity, induces the differentiation of regulatory T cells, and mediates activation-induced cell …
Plasticity of CD4+ T cell lineage differentiation
The differentiation of naive CD4+ T cells into lineages with distinct effector functions has
been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-γ …
been considered to be an irreversible event. T helper type 1 (Th1) cells stably express IFN-γ …