Despite the success in developing various pharmaceutical formulations, most of the active pharmaceutical ingredients (APIs)/drugs, according to the Biopharmaceutics Classification …
Supercritical fluid (SCF) processes have attracted great attention for fabricating micro and nanoparticles in the pharmaceutical applications. Herein we utilized, for the first time, Gas …
A method of rapid expansion of supercritical solutions with solid cosolvent (RESS-SC) was applied, for the first time, to precipitate nanoparticles of Letrozole (LTZ). Solubility of LTZ, as …
F Razmimanesh, G Sodeifian, SA Sajadian - The Journal of Supercritical …, 2021 - Elsevier
The present study practiced ultrasonic-assisted rapid expansion of a supercritical CO 2 solution into a liquid solvent (US-RESOLV) process for the synthesis of nanoparticles (NPs) …
To improve dissolution properties of aprepitant (APR) as a poorly water-soluble drug, Rapid Expansion of Supercritical Solution with Solid Cosolvent (RESS-SC) was applied for the first …
Abstract Effects of the process parameters such as pressure (12–30 MPa), extraction temperature (308–338 K), nozzle length (1–7 mm), nozzle diameter (150–450 μm) and …
The inability of many biopharmaceutical formulations to retain their structure and integrity when in solution represents a major issue for their transport and storage, reducing their shelf …
Poor bioavailability and aqueous solubility represent a major constraint during the development of new API molecules and can influence the impact of new medicines or halt …
The novel particle generation processes of Active Pharmaceutical Ingredient (API)/drug have been extensively explored in recent decades due to their wide-range applications in …