Polymorphism of human cytochrome P450 enzymes and its clinical impact
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …
specific genes affect drug response. This article highlights current pharmacogenetic …
Role of cytochrome P450 2C8 in drug metabolism and interactions
Abstract During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an
important drug-metabolizing enzyme. CYP2C8 is highly expressed in human liver and is …
important drug-metabolizing enzyme. CYP2C8 is highly expressed in human liver and is …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug–drug interactions and …
Y Shitara, Y Sugiyama - Pharmacology & therapeutics, 2006 - Elsevier
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are widely
used for the treatment of hypercholesterolemia. Their efficacy in preventing cardiovascular …
used for the treatment of hypercholesterolemia. Their efficacy in preventing cardiovascular …
Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies
EB Daily, CL Aquilante - Pharmacogenomics, 2009 - Taylor & Francis
Cytochrome P450 (CYP) 2C8 is responsible for the oxidative metabolism of many clinically
available drugs from a diverse number of drug classes (eg, thiazolidinediones, meglitinides …
available drugs from a diverse number of drug classes (eg, thiazolidinediones, meglitinides …
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa
Metabolism of the antimalarial drug amodiaquine (AQ) into its primary metabolite, N‐
desethylamodiaquine, is mediated by CYP2C8. We studied the frequency of CYP2C8 …
desethylamodiaquine, is mediated by CYP2C8. We studied the frequency of CYP2C8 …
Interethnic and Intraethnic Variability of CYP2C8 and CYP2C9 Polymorphisms in Healthy Individuals
E García-Martín, C Martínez, JM Ladero… - Molecular diagnosis & …, 2006 - Springer
Cytochrome P450 (CYP) superfamily members CYP2C8 and CYP2C9 are polymorphically
expressed enzymes that are involved in the metabolic inactivation of several drugs …
expressed enzymes that are involved in the metabolic inactivation of several drugs …
Genetically based impairment in CYP2C8-and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of …
JAG Agúndez, E García-Martín… - Expert opinion on drug …, 2009 - Taylor & Francis
Polymorphisms in CYP2C8 and CYP2C9 are common in all the human populations and
many CYP2C8 and CYP2C9 gene variations cause decreased enzyme activity towards the …
many CYP2C8 and CYP2C9 gene variations cause decreased enzyme activity towards the …
Pharmacogenetic studies of Paclitaxel in the treatment of ovarian cancer
H Green, P Söderkvist, P Rosenberg… - Basic & clinical …, 2009 - Wiley Online Library
The purpose of this study was to evaluate the role of sequence variants in the CYP2C8,
ABCB1 and CYP3A4 genes and the CYP3A4 phenotype for the pharmacokinetics and …
ABCB1 and CYP3A4 genes and the CYP3A4 phenotype for the pharmacokinetics and …
Role of genetic polymorphisms in drug-metabolizing enzyme-mediated toxicity and pharmacokinetic resistance to anti-cancer agents: a review on the …
The inter-individual differences in cancer susceptibility are somehow correlated with the
genetic differences that are caused by the polymorphisms. These genetic variations in drug …
genetic differences that are caused by the polymorphisms. These genetic variations in drug …