WS Powell, J Rokach - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2015 - Elsevier
Arachidonic acid can be oxygenated by a variety of different enzymes, including lipoxygenases, cyclooxygenases, and cytochrome P450s, and can be converted to a …
M Bäck, WS Powell, SE Dahlén… - British journal of …, 2014 - Wiley Online Library
The endogenous ligands for the LT, lipoxin (LX) and oxoeicosanoid receptors are bioactive products produced by the action of the lipoxygenase family of enzymes. The LT receptors …
TL Deem, JM Cook-Mills - Blood, 2004 - ashpublications.org
Lymphocytes bound at endothelial cell junctions extravasate within minutes. Lymphocyte- endothelial cell binding is mediated by receptors such as vascular cell adhesion molecule 1 …
S Nourshargh, FM Marelli-Berg - Trends in immunology, 2005 - cell.com
Leukocyte transmigration is a key event in host defense. As well as delivering leukocytes to sites of inflammation, this response also has an important role in immunity by regulating the …
I Puxeddu, A Alian, AM Piliponsky, D Ribatti… - The international journal …, 2005 - Elsevier
Eosinophils play a crucial role in allergic reactions and asthma. They are also involved in responses against parasites, in autoimmune and neoplastic diseases, and in fibroses. There …
GE Grant, J Rokach, WS Powell - Prostaglandins & other lipid mediators, 2009 - Elsevier
5-Oxo-ETE is a product of the 5-lipoxygenase pathway that is formed by the oxidation of 5- HETE by 5-hydroxyeicosanoid dehydrogenase (5-HEDH). 5-HEDH is a microsomal NADP+ …
Eicosanoids comprise a group of oxidation products of arachidonic and 5, 8, 11, 14, 17- eicosapentaenoic acids formed by oxygenases and downstream enzymes. The two major …
Oxo-ETE (5-oxo-6, 8, 11, 14-eicosatetraenoic acid) is formed from the 5-lipoxygenase product 5-HETE (5S-hydroxy-6, 8, 11, 14-eicosatetraenoic acid) by 5-hydroxyeicosanoid …
Arachidonic acid (all-cis-5, 8, 11, 14-eicosatetraenoic acid, AA) is an essential constituent of cellular membranes, which is released by tightly regulated phospholipase cleavage …