Eosinophils are bone marrow‐derived granulocytes and are found in low numbers in the
peripheral blood of healthy subjects. In type 2 inflammatory diseases, eosinopoiesis in the …

Arachidonic acid can be oxygenated by a variety of different enzymes, including
lipoxygenases, cyclooxygenases, and cytochrome P450s, and can be converted to a …

The endogenous ligands for the LT, lipoxin (LX) and oxoeicosanoid receptors are bioactive
products produced by the action of the lipoxygenase family of enzymes. The LT receptors …

Lymphocytes bound at endothelial cell junctions extravasate within minutes. Lymphocyte-
endothelial cell binding is mediated by receptors such as vascular cell adhesion molecule 1 …

Leukocyte transmigration is a key event in host defense. As well as delivering leukocytes to
sites of inflammation, this response also has an important role in immunity by regulating the …

Eosinophils play a crucial role in allergic reactions and asthma. They are also involved in
responses against parasites, in autoimmune and neoplastic diseases, and in fibroses. There …

5-Oxo-ETE is a product of the 5-lipoxygenase pathway that is formed by the oxidation of 5-
HETE by 5-hydroxyeicosanoid dehydrogenase (5-HEDH). 5-HEDH is a microsomal NADP+ …

Eicosanoids comprise a group of oxidation products of arachidonic and 5, 8, 11, 14, 17-
eicosapentaenoic acids formed by oxygenases and downstream enzymes. The two major …

Oxo-ETE (5-oxo-6, 8, 11, 14-eicosatetraenoic acid) is formed from the 5-lipoxygenase
product 5-HETE (5S-hydroxy-6, 8, 11, 14-eicosatetraenoic acid) by 5-hydroxyeicosanoid …

Arachidonic acid (all-cis-5, 8, 11, 14-eicosatetraenoic acid, AA) is an essential constituent of
cellular membranes, which is released by tightly regulated phospholipase cleavage …