Extracellular matrix reorganization during wound healing and its impact on abnormal scarring

M Xue, CJ Jackson - Advances in wound care, 2015 - liebertpub.com
Significance: When a cutaneous injury occurs, the wound heals via a dynamic series of
physiological events, including coagulation, granulation tissue formation, re …

Destroy to rebuild: the connection between bone tissue remodeling and matrix metalloproteinases

E Hardy, C Fernandez-Patron - Frontiers in physiology, 2020 - frontiersin.org
Bone is a dynamic organ that undergoes constant remodeling, an energetically costly
process by which old bone is replaced and localized bone defects are repaired to renew the …

Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation

M Xue, K McKelvey, K Shen, N Minhas, L March… - …, 2014 - academic.oup.com
Objective. The aim of this study was to investigate the effect of endogenous matrix
metalloproteinases 2 and 9 (MMP-2 and MMP-9) on the invasive characteristics of RA …

Матриксные металлопротеиназы и ингибиторы: классификация, механизм действия

МИ Ярмолинская, АС Молотков… - Журнал акушерства и …, 2012 - cyberleninka.ru
Матриксные металлопротеиназы (MMPs) относятся к семейству внеклеточных
протеиназ и играют важную роль в физиологических и патологических процессах, таких …

Matrix metalloproteinases in bone development and pathology: current knowledge and potential clinical utility

HPH Liang, J Xu, M Xue, CJ Jackson - Metalloproteinases In …, 2016 - Taylor & Francis
Matrix metalloproteinases (MMPs) are degrading enzymes that have a pivotal function in
extracellular matrix remodeling. More than half of the MMP members are expressed by bone …

Role of thrombin-PAR1-PKCθ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood–brain barrier dysfunction in vitro

T Machida, S Dohgu, F Takata, J Matsumoto, I Kimura… - Neuroscience, 2017 - Elsevier
Thrombin, an essential component in the coagulation cascade, participates in the
pathogenesis of brain diseases, such as ischemic stroke, intracerebral hemorrhage …

Vitamin A, D, E, and K as Matrix Metalloproteinase-2/9 regulators that affect expression and enzymatic activity

HVT Vo, YT Nguyen, N Kim, HJ Lee - International journal of molecular …, 2023 - mdpi.com
Fat-soluble vitamins (vitamin A, D, E, and K) assume a pivotal role in maintaining human
homeostasis by virtue of their enzymatic functions. The daily inclusion of these vitamins is …

Glycosaminoglycans in wound healing

J Melrose - Bone and Tissue Regeneration Insights, 2016 - journals.sagepub.com
Glycosaminoglycans (GAGs) are ancient molecules that have persisted throughout
vertebrate and invertebrate evolution for many hundreds of millions of years. They have …

Elevated plasma matrix metalloproteinases and their tissue inhibitors in patients with severe sepsis

P Yazdan-Ashoori, P Liaw, L Toltl, B Webb, G Kilmer… - Journal of critical …, 2011 - Elsevier
PURPOSE: Matrix metalloproteinases (MMPs) are essential for tissue remodeling. Our
objectives were to determine (1) the concentrations of MMPs and their tissue inhibitors …

Differential expression of matrix metalloproteinases 2, 9 and cytokines by neutrophils and monocytes in the clinical forms of Chagas disease

NI Medeiros, RCG Fares, EP Franco… - PLoS neglected …, 2017 - journals.plos.org
Dilated cardiomyopathy, the most severe manifestation in chronic phase of Chagas disease,
affects about 30% of patients and is characterized by myocardial dysfunction and interstitial …