Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …

Since its identification nearly 30 years ago, Lyme disease has continued to spread, and
there have been increasing numbers of cases in the northeastern and north central US. The …

Lyme disease was originally identified in Lyme, Connecticut, based upon an unusual cluster
of what appeared to be patients with juvenile rheumatoid arthritis. It was subsequently …

Before the first description of Lyme arthritis in 1976, patients with this disease were often
thought to have juvenile or adult rheumatoid arthritis. It is now known that Lyme arthritis is …

Lyme borreliosis is caused by a growing list of related, yet distinct, spirochetes with complex
biology and sophisticated immune evasion mechanisms. It may result in a range of clinical …

Gene expression analysis previously revealed a robust IFN-responsive gene induction
profile that was selectively up-regulated in Borrelia burgdorferi-infected C3H mice at 1 wk …

ABSTRACT Interleukin-10 (IL-10) modulates inflammatory responses elicited in vitro and in
vivo by Borrelia burgdorferi, the Lyme disease spirochete. How IL-10 modulates these …

After infection with Borrelia species, the risk for developing Lyme disease varies significantly
between individuals. Recognition of Borrelia by the immune system is mediated by pattern …

Objective In a murine model of antibiotic‐refractory Lyme arthritis, the numbers of Treg cells
are dramatically reduced. The aim of this study was to examine Treg cell numbers and …

Borrelia burgdorferi stimulates a robust inflammatory response at sites of localization.
Binding of borrelial lipoproteins to TLR-2 is one pathway important in the host response to B …