The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

Mechanisms of Glucocorticoid-Induced Insulin Resistance - Endocrinology and Metabolism
Clinics Skip to Main Content Skip to Main Menu Advertisement Endocrinology and …

Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are
associated with intestinal and systemic pathologies. Interactions between bacterial products …

The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …

Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …

The prevalence of use of long-term systemic glucocorticoid therapy in the general adult
population is 1%. This figure increases to up to 3% in elderly women. Metabolic (ie diabetes …

Both obesity and sarcopenia are frequently associated in ageing, and together may promote
the progression of related conditions such as diabetes and frailty. However, little is known …

Cushing's syndrome (CS) patients have increased mortality primarily due to cardiovascular
events induced by glucocorticoid (GC) excess-related severe metabolic changes. Glucose …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the global obesity
and metabolic disease epidemic and is rapidly becoming the leading cause of liver cirrhosis …

Inflammation is a complex process which is highly conserved among species. Inflammation
occurs in response to injury, infection, and cancer, as an allostatic mechanism to return the …