Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced
histamine release from rabbit platelets producing antibodies in passive cutaneous …

Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates
tumor cell debris that may stimulate inflammation and tumor growth. Thus, conventional …

Although chemotherapy is a conventional cancer treatment, it may induce a protumorigenic
microenvironment by triggering the release of proinflammatory mediators. In this study, we …

Described almost 50 years ago, the glycerophosphocholine lipid mediator Platelet-activating
factor (PAF) has been implicated in many pathologic processes. Indeed, elevated levels of …

Angiogenesis, the growth of new blood vessels, plays a critical role in tissue repair and
regeneration, as well as in cancer. A paradigm shift is emerging in our understanding of the …

Studies of secondary metabolites (natural products) that cover their isolation, chemical
synthesis and bioactivity investigation present myriad opportunities for discovery. For …

Toxic environmental carcinogens promote cancer via genotoxic and nongenotoxic
pathways, but nongenetic mechanisms remain poorly characterized. Carcinogen-induced …

Cervical cancer continues to be a public health problem in developing countries. Previous
studies have shown that cervical cancer cells display markers of aerobic glycolysis …

When tumor cells are killed by targeted therapy, radiotherapy, or chemotherapy, they trigger
their primary tumor by releasing pro-inflammatory cytokines. Microenvironmental …