Ion channels are integral membrane proteins present on the plasma membrane as well as
intracellular membranes. In the human genome, there are more than 400 known genes …

In recent decades, growing scientific evidence supports the role of ion channels in the
development of different cancers. Both potassium selective pores and chloride …

Membrane protrusion and adhesion to the extracellular matrix, which involves the extension
of actin filaments and formation of adhesion complexes, are the fundamental processes for …

Intracellular organelles are membranous structures central for maintaining cellular
physiology and the overall health of the cell. To maintain cellular function, intracellular …

Chloride intracellular channel protein 1 (CLIC1) is very unusual as it adopts a soluble
glutathione S-transferase-like canonical fold but can also autoinsert into lipid bilayers to form …

Key points Accumulation of inorganic phosphate (Pi) may contribute to muscle fatigue by
precipitating calcium salts inside the sarcoplasmic reticulum (SR). Neither direct …

Simple Summary Although chloride intracellular channel proteins (CLICs) have been
identified as ion channel proteins, their true functions are still elusive. Recent in silico …

摘要目的探究胞内氯离子通道蛋白1 (CLIC1) 的缺失突变体CLIC1 (Δ49-51)
在哺乳动物细胞中的表达, 定位改变, 及与Sedlin 蛋白在体内, 体外相互作用的影响 …