Hyperinsulinemia and its pivotal role in aging, obesity, type 2 diabetes, cardiovascular disease and cancer

JA Janssen - International journal of molecular sciences, 2021 - mdpi.com
For many years, the dogma has been that insulin resistance precedes the development of
hyperinsulinemia. However, recent data suggest a reverse order and place …

Coronary artery disease: from mechanism to clinical practice

C Shao, J Wang, J Tian, Y Tang - Coronary Artery Disease: Therapeutics …, 2020 - Springer
In most developed countries, coronary artery disease (CAD), mostly caused by
atherosclerosis of coronary arteries, is one of the primary causes of death. From 1990s to …

Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome

BL Wajchenberg - Endocrine reviews, 2000 - academic.oup.com
Methods for assessment, eg., anthropometric indicators and imaging techniques, of several
phenotypes of human obesity, with special reference to abdominal fat content, have been …

Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol

HB Rubins, SJ Robins, D Collins, CL Fye… - … England Journal of …, 1999 - Mass Medical Soc
Background Although it is generally accepted that lowering elevated serum levels of low-
density lipoprotein (LDL) cholesterol in patients with coronary heart disease is beneficial …

Impact of metabolic syndrome on cognition and brain: a selected review of the literature

KF Yates, V Sweat, PL Yau… - … , and vascular biology, 2012 - Am Heart Assoc
Metabolic syndrome (MetS), a clustering of risk factors for type 2 diabetes mellitus and
cardiovascular disease, has been associated with cognitive dysfunction and brain …

The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes

R Kahn, J Buse, E Ferrannini, M Stern - Diabetes care, 2005 - Am Diabetes Assoc
The term “metabolic syndrome” refers to a clustering of specific cardiovascular disease
(CVD) risk factors whose underlying pathophysiology is thought to be related to insulin …

The metabolic syndrome: prevalence in worldwide populations

AJ Cameron, JE Shaw… - … and Metabolism Clinics, 2004 - endo.theclinics.com
The concept of the metabolic syndrome has now been in existence for several decades;
however, it has only been since some agreement on definitions of the syndrome was …

Prospective analysis of the insulin-resistance syndrome (syndrome X)

SM Haffner, RA Valdez, HP Hazuda, BD Mitchell… - Diabetes, 1992 - Am Diabetes Assoc
Many studies have shown that hyperinsulinemia and/or insulin resistance are related to
various metabolic and physiological disorders including hypertension, dyslipidemia, and …

Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease

JB Meigs, PWF Wilson, CS Fox… - The Journal of …, 2006 - academic.oup.com
Context: Metabolic risk conferred by adiposity may be due to associated risk factor
clustering. Objective: The objective of this study was to assess risk for diabetes or …

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

JC Pickup, MB Mattock, GD Chusney, D Burt - Diabetologia, 1997 - Springer
Non-insulin-dependent diabetes mellitus (NIDDM) is commonly associated with hypertrigly-
ceridaemia, low serum HDL-cholesterol concentrations, hypertension, obesity and …