Current advances in Zika vaccine development

Y Wang, L Ling, Z Zhang, A Marin-Lopez - Vaccines, 2022 - mdpi.com
Zika virus (ZIKV), an emerging arthropod-borne flavivirus, was first isolated in Uganda in
1947 from monkeys and first detected in humans in Nigeria in 1952; it has been associated …

Poxviruses and the immune system: Implications for monkeypox virus

A Saghazadeh, N Rezaei - International Immunopharmacology, 2022 - Elsevier
Poxviruses (PXVs) are mostly known for the variola virus, being the cause of smallpox;
however, re-emerging PXVs have also shown a great capacity to develop outbreaks of pox …

[HTML][HTML] Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis

DJ Rawle, T Dumenil, B Tang, CR Bishop, K Yan… - Science of the Total …, 2022 - Elsevier
Global microplastic (MP) contamination and the effects on the environment are well
described. However, the potential for MP consumption to affect human health remains …

Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

DJ Rawle, TT Le, T Dumenil, C Bishop, K Yan… - elife, 2022 - elifesciences.org
Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma-/-
mouse studies having informed our understanding of GZMA's physiological function. We …

Identification and validation of an autophagy-related signature for predicting survival in lower-grade glioma

S Feng, H Liu, X Dong, P Du, H Guo, Q Pang - Bioengineered, 2021 - Taylor & Francis
Abnormal levels of autophagy have been implicated in the pathogenesis of multiple
diseases, including cancer. However, little is known about the role of autophagy-related …

Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung

CR Bishop, K Yan, W Nguyen, DJ Rawle… - Frontiers in …, 2024 - frontiersin.org
Introduction Global microplastic (MP) pollution is now well recognized, with humans and
animals consuming and inhaling MPs on a daily basis, with a growing body of concern …

Generating prophylactic immunity against arboviruses in vertebrates and invertebrates

DJ Rawle, LE Hugo, AL Cox, GJ Devine… - Nature Reviews …, 2024 - nature.com
Abstract The World Health Organization recently declared a global initiative to control
arboviral diseases. These are mainly caused by pathogenic flaviviruses (such as dengue …

EDIII-Fc induces protective immune responses against the Zika virus in mice and rhesus macaque

H Su, J Liu, J Yu, Z Qiu, W Liang, W Wu… - PLOS Neglected …, 2023 - journals.plos.org
Zika virus can infect the fetus through the placental barrier, causing ZIKV congenital
syndrome and even miscarriage, which can cause great harm to pregnant women and …

Novel recombinant vaccinia virus-vectored vaccine affords complete protection against homologous Borrelia burgdorferi infection in mice

A Pfeifle, W Zhang, J Cao… - Emerging Microbes & …, 2024 - Taylor & Francis
The rising prevalence of Lyme disease (LD) in North America and Europe has emerged as a
pressing public health concern. Despite the availability of veterinary LD vaccines, no …

The vaccinia‐based Sementis Copenhagen Vector coronavirus disease 2019 vaccine induces broad and durable cellular and humoral immune responses

P Eldi, TH Cooper, NA Prow, L Liu… - … and Cell Biology, 2022 - Wiley Online Library
The ongoing coronavirus disease 2019 (COVID‐19) pandemic perpetuated by severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants has highlighted the continued …