Background Adenovirus-vectored (Ad-vectored) vaccines are typically administered via im
injection to humans and are incapable of inducing respiratory mucosal immunity. However …

Asthma is a complex multigenic disease. The most frequently encountered form is atopic
asthma, which is at its highest prevalence during childhood/young adulthood, and this …

We investigated the in vivo function of the B7 family member B7-H3 (also known as B7RP-2)
by gene targeting. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor …

The outcome of T-cell responses after T-cell encounter with specific antigens is modulated
by co-stimulatory signals, which are required for both lymphocyte activation and …

Over the last decade there has been an intense interest in the potential role of cytokines and
chemokines as important mediators in various atopic diseases, including asthma and the …

Pulmonary Cryptococcus neoformans infection of C57BL/6 mice is an established model of
a chronic pulmonary fungal infection accompanied by an “allergic” response (T2) to the …

In yeast (Saccharomyces cerevisiae), transcriptional activators, such as Gal4 and Gal4–
VP16, work ordinarily from sites located in the upstream activating sequence (UAS) …

In this study we examined the effect of oral antigen (Ag) administration on the development
of experimental asthma in different mouse strains. We selected BALB/c, BP2, CBA/Ca …

The objective of this study was to investigate the effect of airway gene transfer of interleukin
(IL)-10, a cytokine with potent anti-inflammatory and immunoregulatory activities, on allergic …

Rationale: Mouse models of allergic airway disease have greatly contributed to our
understanding of disease induction and pathogenesis. Although these models typically …