Protease-activated receptors in health and disease
CJ Peach, LE Edgington-Mitchell… - Physiological …, 2023 - journals.physiology.org
Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …
protease-activated receptors (PARs). The four known PARs are members of the large family …
Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases
DM Heuberger, RA Schuepbach - Thrombosis journal, 2019 - Springer
Inflammatory diseases have become increasingly prevalent with industrialization. To
address this, numerous anti-inflammatory agents and molecular targets have been …
address this, numerous anti-inflammatory agents and molecular targets have been …
Remodelling of the tumour microenvironment by the kallikrein-related peptidases
Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …
Structure, function and pathophysiology of protease activated receptors
Discovered in the 1990s, protease activated receptors 1 (PARs) are membrane-spanning
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …
Dental enamel development: proteinases and their enamel matrix substrates
JD Bartlett - International Scholarly Research Notices, 2013 - Wiley Online Library
This review focuses on recent discoveries and delves in detail about what is known about
each of the proteins (amelogenin, ameloblastin, and enamelin) and proteinases (matrix …
each of the proteins (amelogenin, ameloblastin, and enamelin) and proteinases (matrix …
Biased signaling of protease-activated receptors
P Zhao, M Metcalf, NW Bunnett - Frontiers in endocrinology, 2014 - frontiersin.org
In addition to their role in protein degradation and digestion, proteases can also function as
hormone-like signaling molecules that regulate vital patho-physiological processes …
hormone-like signaling molecules that regulate vital patho-physiological processes …
Targeting proteinase-activated receptors: therapeutic potential and challenges
Abstract Proteinase-activated receptors (PARs), a family of four seven-transmembrane G
protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs …
protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs …
PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancer
M Song, D Chen, B Lu, C Wang, J Zhang, L Huang… - PloS one, 2013 - journals.plos.org
Background Programmed death ligand-1 (PD-L1) has been identified as a factor associated
with poor prognosis in a range of cancers, and was reported to be mainly induced by PTEN …
with poor prognosis in a range of cancers, and was reported to be mainly induced by PTEN …
Unleashing the therapeutic potential of human kallikrein-related serine proteases
Tissue kallikreins are a family of fifteen secreted serine proteases encoded by the largest
protease gene cluster in the human genome. In the past decade, substantial progress has …
protease gene cluster in the human genome. In the past decade, substantial progress has …
Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus
MG Lawrence, J Lai, JA Clements - Endocrine reviews, 2010 - academic.oup.com
The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-
specific expression profiles and putative proteolytic functions. The kallikrein family is also …
specific expression profiles and putative proteolytic functions. The kallikrein family is also …