In this review glycosidase activated prodrugs that target cancer cells are discussed.
Glycosylated prodrugs undergo enzymatic bioconversion, cleaving the prodrug to release …

The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …

Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or
chemical transformation in vivo to release the active parent drug, which can then exert the …

The current review presents an update of drug delivery using poly (ethylene glycol)(PEG),
that focuses on recent developments in both protein and organic drugs. Certainly the past 10 …

Prodrugs are an established concept to overcome barriers to a drug's usefulness. In
Germany, about 6.9% of all marketed medicines can be classified as prodrugs, an estimate …

Classical prodrug design often represents a nonspecific chemical approach to mask
undesirable drug properties such as limited bioavailability, lack of site specificity, and …

[57] ABSTRACT'This invention relates to a novel method for the deliv ery of cytotoxic drugs
to tumor-cells by the administra tion of a tumor-speci? c antibody-enzyme conjugate that …

Enzymes are essential for the activation of many prodrugs. In this review, the most important
enzymes (eg, paraoxonase, carboxylesterase, acetylcholinesterase, cholinesterase) …

The objective of this Commentary is to help clarify and illustrate what prodrugs are, what
they are not, which benefits they can offer, and what their limits are. To this end, a number of …

No low molecular weight (< 20 000) poly (ethylene glycol)(PEG) small molecule drug
conjugates, prepared over a 20-year period, have led to a clinically approved product. In this …