D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications

J Favresse, G Lippi, PM Roy, B Chatelain… - Critical reviews in …, 2018 - Taylor & Francis
D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated
degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of …

Advantages and limitations of total laboratory automation: a personal overview

G Lippi, G Da Rin - Clinical Chemistry and Laboratory Medicine …, 2019 - degruyter.com
Automation is considered one of the most important breakthroughs in the recent history of
laboratory diagnostics. In a model of total laboratory automation (TLA), many analyzers …

[HTML][HTML] Liver function tests

V Lala, M Zubair, D Minter - StatPearls, 2023 - statpearls.com
The liver, located in the right upper quadrant of the body and below the diaphragm, is
responsible for several functions, including primary detoxification of various metabolites …

Preanalytics and precision pathology: pathology practices to ensure molecular integrity of cancer patient biospecimens for precision medicine

CC Compton, JA Robb… - … of pathology & …, 2019 - meridian.allenpress.com
Biospecimens acquired during routine medical practice are the primary sources of molecular
information about patients and their diseases that underlies precision medicine and …

How to optimize activated partial thromboplastin time (APTT) testing: solutions to establishing and verifying normal reference intervals and assessing APTT reagents …

EJ Favaloro, G Kershaw… - … in thrombosis and …, 2019 - thieme-connect.com
The activated partial thromboplastin time (APTT) assay is a very common coagulation test,
used for several reasons. The test is conventionally used for assessing the contact factor …

The known unknowns: an overview of the state of blood-based protein biomarkers of mild traumatic brain injury

SJ McDonald, SR Shultz, DV Agoston - Journal of Neurotrauma, 2021 - liebertpub.com
Blood-based protein biomarkers have revolutionized several fields of medicine by enabling
molecular level diagnosis, as well as monitoring disease progression and treatment efficacy …

Fusion‐positive non‐small cell lung carcinoma: biological principles, clinical practice, and diagnostic implications

D Kazdal, V Hofman, P Christopoulos… - Genes …, 2022 - Wiley Online Library
Based on superior efficacy and tolerability, targeted therapy is currently preferred over
chemotherapy and/or immunotherapy for actionable gene fusions that occur in late‐stage …

[HTML][HTML] Alanine amino transferase

KE Moriles, SA Azer - 2020 - europepmc.org
The liver has a central and critical biochemical role in the metabolism, digestion,
detoxification, and elimination of substances from the body. All blood from the intestinal tract …

Microsampling tools for collecting, processing, and storing blood at the point‐of‐care

KR Baillargeon, CR Mace - Bioengineering & Translational …, 2023 - Wiley Online Library
In the wake of the COVID‐19 global pandemic, self‐administered microsampling tools have
reemerged as an effective means to maintain routine healthcare assessments without …

An overview of the most important preanalytical factors influencing the clinical performance of SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs)

G Lippi, BM Henry, M Plebani - Clinical Chemistry and Laboratory …, 2023 - degruyter.com
Due to the many technical limitations of molecular biology, the possibility to sustain
enormous volumes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …