Trialenroll: Predicting clinical trial enrollment success with deep & cross network and large language models

L Yue, S Xing, J Chen, T Fu - Proceedings of the 15th ACM International …, 2024 - dl.acm.org
Clinical trials need to recruit a sufficient number of volunteer patients to demonstrate the
statistical power of the treatment (eg, a new drug) in curing a certain disease. Clinical trial …

Smiles-mamba: Chemical mamba foundation models for drug admet prediction

B Xu, Y Lu, C Li, L Yue, X Wang, N Hao, T Fu… - arXiv preprint arXiv …, 2024 - arxiv.org
In drug discovery, predicting the absorption, distribution, metabolism, excretion, and toxicity
(ADMET) properties of small-molecule drugs is critical for ensuring safety and efficacy …

Drugclip: Contrastive drug-disease interaction for drug repurposing

Y Lu, Y Hu, C Li - arXiv preprint arXiv:2407.02265, 2024 - arxiv.org
Bringing a novel drug from the original idea to market typically requires more than ten years
and billions of dollars. To alleviate the heavy burden, a natural idea is to reuse the approved …

Clinicalagent: Clinical trial multi-agent system with large language model-based reasoning

L Yue, S Xing, J Chen, T Fu - Proceedings of the 15th ACM International …, 2024 - dl.acm.org
Large Language Models (LLMs) and multi-agent systems have shown impressive
capabilities in natural language tasks but face challenges in clinical trial applications …

Retrieval-Reasoning Large Language Model-based Synthetic Clinical Trial Generation

Z Xu, F Wu, T Fu, Y Zhao - arXiv preprint arXiv:2410.12476, 2024 - arxiv.org
Machine learning (ML) exhibits promise in the clinical domain. However, it is constrained by
data scarcity and ethical considerations, as the generation of clinical trials presents …

Analysis of the Most Important Variables Impacting Clinical Trial Success Rates

A Kangas - 2024 - diva-portal.org
Clinical trial research is imperative to find new treatments for various diseases or conditions.
However, as trials have become more complex, a significant number are experiencing …