The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …

The past decade has witnessed a major increase in our understanding of the genetic
underpinnings of childhood cancer. Genomic sequencing studies have highlighted key …

The primary results of the first round of pediatric precision oncology clinical trials will provide
us with a greater understanding of the clinical impact of linking tumor profiling to selection of …

Childhood acute lymphoblastic leukemia (ALL) genomes show that relapses often arise from
subclonal outgrowths. However, the impact of clonal evolution on the actionable proteome …

There has been increasing interest and rapid developments in precision medicine, which is
a new medical concept and model based on individualized medicine with the joint …

Over the past 40 years, the 5-years-overall survival rate of pediatric cancer reached 75–
80%, and for acute lymphoblastic leukemia (ALL), exceeded 90%. Leukemia continues to be …

To inform clinical trial design and real-world precision pediatric oncology practice, we
classified diagnoses, assessed the landscape of mutations, and identified genomic variants …

Despite huge advances in the diagnosis and treatment of pediatric cancers over the past
several decades, it remains one of the leading causes of death during childhood in …

Background Prevalent symptoms that affect children and adolescents throughout the
process of cancer diagnosis and treatment include nausea and vomiting, fatigue, pain …

Introduction: Cancer changes the proteome in complex ways that reach well beyond simple
changes in protein abundance. Genomic and transcriptional variations and post …