Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Aging is the primary risk factor underlying hypertension and incident cardiovascular disease.
With aging, the vasculature undergoes structural and functional changes characterized by …

The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

The aging process is associated with loss of muscle mass and strength and decline in
physical functioning. The term sarcopenia is primarily defined as low level of muscle mass …

Older people constitute an increasingly greater proportion of patients with advanced CKD,
including those patients undergoing maintenance dialysis treatment. Frailty is a biologic …

Skeletal muscle mass, quality and adaptability are fundamental in promoting muscle
performance, maintaining metabolic function and supporting longevity and healthspan …

Some of the most serious consequences of ageing are its effects on skeletal muscle. The
term 'sarcopenia'describes the slow but progressive loss of muscle mass with advancing …

Background Investigations into both the pathophysiology and therapeutic targets in muscle
dystrophies have been hampered by the limited proliferative capacity of human myoblasts …

Objective To characterize muscle fiber necrosis in immune-mediated necrotizing myopathies
(IMNM) with anti–signal recognition particle (SRP) or anti–3-hydroxy-3 …

Advancing age is associated with a progressive loss of skeletal muscle (SkM) mass and
function. Given the worldwide aging demographics, this is a major contributor to morbidity …