TMEM164 is a new determinant of autophagy-dependent ferroptosis

J Liu, Y Liu, Y Wang, C Li, Y Xie, DJ Klionsky, R Kang… - Autophagy, 2023 - Taylor & Francis
ABSTRACT Macroautophagy (hereafter “autophagy”) is a membrane-mediated biological
process that involves engulfing and delivering cytoplasmic components to lysosomes for …

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9

S Yang, D Park, L Manning, SE Hill, M Cao, Z Xuan… - Neuron, 2022 - cell.com
Autophagy is a cellular degradation pathway essential for neuronal health and function.
Autophagosome biogenesis occurs at synapses, is locally regulated, and increases in …

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts

D Smith, G Kannan, I Coppens, F Wang, HM Nguyen… - Elife, 2021 - elifesciences.org
Many of the world's warm-blooded species are chronically infected with Toxoplasma gondii
tissue cysts, including an estimated one-third of the global human population. The cellular …

Toxoplasma TgAtg8-TgAtg3 Interaction Primarily Contributes to Apicoplast Inheritance and Parasite Growth in Tachyzoite

L Cheng, Y Tian, Y Wang, T Wang, Y Yao… - Microbiology …, 2022 - Am Soc Microbiol
The apicoplast, which harbors key pathways involved in biosynthesis of vital metabolites, is
a unique and essential nonphotosynthetic plastid organelle in apicomplexan parasites …

The active zone protein Clarinet regulates ATG-9 trafficking at synapses and presynaptic autophagy

Z Xuan, S Yang, SE Hill, B Clark, L Manning… - bioRxiv, 2021 - biorxiv.org
In neurons, autophagy is temporally and spatially regulated to occur near presynaptic sites.
How trafficking of autophagy proteins is regulated to support synaptic autophagy is not well …

Improved volume CLEM revealed that aberrant phagophores and RB1CC1/FIP200-containing clusters appear surround SQSTM1/p62 aggregates in Atg9a-deficient …

S Kakuta, J Yamaguchi, C Suzuki, I Tanida… - Autophagy …, 2023 - Taylor & Francis
ABSTRACT ATG9A is an important membrane protein in mammalian macroautophagy. The
formation of autophagosomes and phagophores is blocked in atg9a KO cells. However, it …

ATG9 vesicles are a subtype of intracellular nanovesicle

M Fesenko, DJ Moore, P Ewbank, E Courthold… - bioRxiv, 2024 - biorxiv.org
Cells are filled with thousands of vesicles, which mediate protein transport and ensure
homeostasis of the endomembrane system. Distinguishing these vesicles functionally and …

Molecular Mechanisms of ATG-9 Localization and Function in Neurons

S Yang - 2022 - search.proquest.com
Autophagy is a cellular degradation pathway essential for neuronal health and function.
Autophagosome biogenesis occurs at synapses, is locally regulated and increases in …