Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

Granules are essential for the ability of neutrophils to fulfill their role in innate immunity.
Granule membranes contain proteins that react to environmental cues directing neutrophils …

Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production
throughout postnatal life. Haematopoiesis first emerges in human BM at 11–12 weeks after …

Delineating hierarchical cellular states, including rare intermediates and the networks of
regulatory genes that orchestrate cell-type specification, are continuing challenges for …

Neutrophils have traditionally been thought of as simple foot soldiers of the innate immune
system with a restricted set of pro-inflammatory functions. More recently, it has become …

Within the bone marrow, stem cells differentiate and give rise to diverse blood cell types and
functions. Currently, hematopoietic progenitors are defined using surface markers combined …

Neutrophils are produced in the bone marrow from stem cells that proliferate and
differentiate to mature neutrophils fully equipped with an armory of granules. These contain …

The mammalian inflammatory response is a rapid and complex physiological reaction to
noxious stimuli including microbial pathogens. Although inflammation plays a valuable role …

Monocytes influence multiple aspects of tumor progression, including antitumor immunity,
angiogenesis, and metastasis, primarily by infiltrating tumors, and differentiating into tumor …

Monocytes are circulating blood leukocytes that play important roles in the inflammatory
response, which is essential for the innate response to pathogens. But inflammation and …