Toxicity of amphetamines: an update

M Carvalho, H Carmo, VM Costa, JP Capela… - Archives of …, 2012 - Springer
Amphetamines represent a class of psychotropic compounds, widely abused for their
stimulant, euphoric, anorectic, and, in some cases, emphathogenic, entactogenic, and …

Central role of mitochondria in drug-induced liver injury

D Pessayre, B Fromenty, A Berson… - Drug metabolism …, 2012 - Taylor & Francis
A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive
metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events …

Piperazine compounds as drugs of abuse

MD Arbo, ML Bastos, HF Carmo - Drug and alcohol dependence, 2012 - Elsevier
Synthetic drugs are among the most commonly abused drugs in the world. This abuse is
widespread among young people, especially in the dance club and rave scenes. Over the …

Raising awareness of new psychoactive substances: chemical analysis and in vitro toxicity screening of 'legal high'packages containing synthetic cathinones

AM Araújo, MJ Valente, M Carvalho… - Archives of …, 2015 - Springer
The world's status quo on recreational drugs has dramatically changed in recent years due
to the rapid emergence of new psychoactive substances (NPS), represented by new narcotic …

Contribution of catecholamine reactive intermediates and oxidative stress to the pathologic features of heart diseases

VM Costa, F Carvalho, ML Bastos… - Current medicinal …, 2011 - ingentaconnect.com
Pathologic heart conditions, particularly heart failure (HF) and ischemia-reperfusion (I/R)
injury, are characterized by sustained elevation of plasma and interstitial catecholamine …

Role of inflammation and redox status on doxorubicin-induced cardiotoxicity in infant and adult CD-1 male mice

A Reis-Mendes, AI Padrão, JA Duarte… - Biomolecules, 2021 - mdpi.com
Doxorubicin (DOX) is a topoisomerase II inhibitor commonly used in the treatment of several
types of cancer. Despite its efficacy, DOX can potentially cause fatal adverse effects, like …

Ecstasy: are animal data consistent between species and can they translate to humans?

N Easton, CA Marsden - Journal of Psychopharmacology, 2006 - journals.sagepub.com
The number of 3, 4-methylenedioxymethamphetamine (ecstasy or MDMA) animal research
articles is rapidly increasing and yet studies which place emphasis on the clinical signi …

3, 4-Methylenedioxypyrovalerone (MDPV): in vitro mechanisms of hepatotoxicity under normothermic and hyperthermic conditions

MJ Valente, AM Araújo, R Silva, ML Bastos… - Archives of …, 2016 - Springer
Synthetic cathinones have emerged in recreational drug markets as legal alternatives for
classical amphetamines. Though currently banned in several countries, 3, 4 …

Chiral enantioresolution of cathinone derivatives present in “legal highs”, and enantioselectivity evaluation on cytotoxicity of 3, 4-methylenedioxypyrovalerone (MDPV)

B Silva, C Fernandes, ME Tiritan, MMM Pinto… - Forensic toxicology, 2016 - Springer
Recently, great interest has been focused on synthetic cathinones since their consumption
has increased exponentially. All synthetic cathinones exist as chiral molecules; the …

MDMA: interactions with other psychoactive drugs

WMY Mohamed, SB Hamida, JC Cassel… - Pharmacology …, 2011 - Elsevier
3, 4-Methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most widely abused
illegal drugs. Some users self-report euphoria and an increased perception and feeling of …