Mass spectrometry of nucleic acid noncovalent complexes
Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
A perspective of polyamine metabolism
HM Wallace, AV Fraser, A Hughes - Biochemical Journal, 2003 - portlandpress.com
Polyamines are essential for the growth and function of normal cells. They interact with
various macromolecules, both electrostatically and covalently and, as a consequence, have …
various macromolecules, both electrostatically and covalently and, as a consequence, have …
DNA: structure and function
RR Sinden, CE Pearson, VN Potaman… - Advances in genome …, 1998 - Elsevier
Publisher Summary This chapter discusses the structure and function of DNA. DNA occupies
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …
Polyamine-dependent gene expression
AC Childs, DJ Mehta, EW Gerner - Cellular and Molecular Life Sciences …, 2003 - Springer
The polyamines spermidine and spermine along with the diamine putrescine are involved in
many cellular processes, including chromatin condensation, maintenance of DNA structure …
many cellular processes, including chromatin condensation, maintenance of DNA structure …
Sequence‐specific recognition and modification of double‐helical DNA by oligonucleotides
NT Thuong, C Hélène - Angewandte Chemie International …, 1993 - Wiley Online Library
Nucleic acids can be selectively recognized by a large number of natural and synthetic
ligands. Oligonucleotides provide the highest specificity of recognition. They can bind to a …
ligands. Oligonucleotides provide the highest specificity of recognition. They can bind to a …
[PDF][PDF] H-DNA and related structures
SM Mirkin, MD Frank-Kamenetskii - Annual review of biophysics …, 1994 - researchgate.net
542 MIRKIN & FRANK-KAMENETSKII and cruciform formation in supercoiled plasmids (71,
97, 116) stimulated interest in unusual DNA conformations and their possible biological role …
97, 116) stimulated interest in unusual DNA conformations and their possible biological role …
Potential in vivo roles of nucleic acid triple-helices
The ability of double-stranded DNA to form a triple-helical structure by hydrogen bonding
with a third strand is well established, but the biological functions of these structures remain …
with a third strand is well established, but the biological functions of these structures remain …
A new DNA nanostructure, the G-wire, imaged by scanning probe microscopy
TC Marsh, J Vesenka, E Henderson - Nucleic acids research, 1995 - academic.oup.com
G-DNA is a polymorphic family of quadruple helical nucleic acid structures containing
guanine tetrad motifs [G-quartets; Willlamson, JR, Raghuraman. MK and CechJ. R.(1989) …
guanine tetrad motifs [G-quartets; Willlamson, JR, Raghuraman. MK and CechJ. R.(1989) …
Triplex DNA: fundamentals, advances, and potential applications for gene therapy
PP Chan, PM Glazer - Journal of Molecular Medicine, 1997 - Springer
The ability to target specific sequences of DNA through oligonucleotide-based triple-helix
formation provides a powerful tool for genetic manipulation. Under experimental conditions …
formation provides a powerful tool for genetic manipulation. Under experimental conditions …
Targeting DNA with triplexes
KR Fox - Current medicinal chemistry, 2000 - ingentaconnect.com
The formation of intermolecular DNA triple helices offers the possibility of designing
compounds with extensive sequence recognition properties which may be useful as …
compounds with extensive sequence recognition properties which may be useful as …