Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin …

C Mouffouk, S Mouffouk, S Mouffouk… - European journal of …, 2021 - Elsevier
The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The …

Molecular Basis of the Therapeutical Potential of Clove (Syzygium aromaticum L.) and Clues to Its Anti-COVID-19 Utility

C Vicidomini, V Roviello, GN Roviello - Molecules, 2021 - mdpi.com
The current COronaVIrus Disease 19 (COVID-19) pandemic caused by SARS-CoV-2
infection is enormously affecting the worldwide health and economy. In the wait for an …

Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions

A Goc, W Sumera, M Rath, A Niedzwiecki - PLoS One, 2021 - journals.plos.org
In the pursuit of suitable and effective solutions to SARS-CoV-2 infection, we investigated
the efficacy of several phenolic compounds in controlling key cellular mechanisms involved …

Bee products as a source of promising therapeutic and chemoprophylaxis strategies against COVID‐19 (SARS‐CoV‐2)

WG Lima, JCM Brito… - Phytotherapy …, 2021 - Wiley Online Library
The emergence of novel coronavirus (SARS‐CoV‐2) in 2019 in China marked the third
outbreak of a highly pathogenic coronavirus infecting humans. The novel coronavirus …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

Exploring the treatment of COVID‐19 with Yinqiao powder based on network pharmacology

H Lin, X Wang, M Liu, M Huang, Z Shen… - Phytotherapy …, 2021 - Wiley Online Library
Coronavirus disease 2019 (COVID‐19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS‐CoV‐2). In China, Yinqiao powder is widely used to prevent and treat …

[HTML][HTML] Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E

Y Zhu, F Scholle, SC Kisthardt, DY Xie - Virology, 2022 - Elsevier
Since December 2019, the deadly novel severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has caused the current COVID-19 pandemic. To date, vaccines are available …

Pomegranate: Nutraceutical with promising benefits on human health

A Caruso, A Barbarossa, A Tassone, J Ceramella… - Applied sciences, 2020 - mdpi.com
Pomegranate is an old plant made up by flowers, roots, fruits and leaves, native to Central
Asia and principally cultivated in the Mediterranean and California (although now …

Chemical Compositions of Clove (Syzygium aromaticum (L.) Merr. & L.) Extracts and Their Potentials in Suppressing SARS-CoV-2 Spike Protein–ACE2 Binding …

Y Li, Z Liu, M Zeng, A El Kadiri, J Huang… - Journal of Agricultural …, 2022 - ACS Publications
COVID-19 is initiated by binding the SARS-CoV-2 spike protein to angiotensin-converting
enzyme 2 (ACE2) on host cells. Food factors capable of suppressing the binding between …

Drug design strategies for the treatment of viral disease. Plant phenolic compounds and their derivatives

M Kowalczyk, A Golonko, R Świsłocka… - Frontiers in …, 2021 - frontiersin.org
The coronavirus pandemic (SARS CoV-2) that has existed for over a year, constantly forces
scientists to search for drugs against this virus. In silico research and selected experimental …