Natural biological enzymes possess catalytic sites that are generally surrounded by a large
three-dimensional scaffold. However, the proportion of the protein molecule that participates …

Given the similar chemical properties of zinc and cadmium, zinc finger domains have been
often proposed as mediators of the toxic and carcinogenic effects exerted by this xenobiotic …

In the funneled landscape, proteins fold to their native states through a stochastic process in
which the free energy decreases spontaneously and unfolded, transition, native, and …

A quantum calibrated polarizable-charge transfer force field (QPCT) has been proposed to
accurately describe the interaction dynamics of zinc–protein complexes. The parameters of …

Zinc ion binding is a principal event in the achievement of the correct fold in classical zinc
finger domains since the motif is largely unfolded in the absence of metal. In the case of a …

X-linked inhibitor of apoptosis protein (XIAP) deficiency causes refractory inflammatory
bowel disease. The XIAP protein plays a pivotal role in the pro-inflammatory response …

In recent years, some transcription factors have been observed to remain associated with
mitotic chromatin. Based on these observations, it is suggested that these chromatin-bound …

The protein vitellogenin (Vg) plays a central role in lipid transportation in most egg‐laying
animals. High Vg levels correlate with stress resistance and lifespan potential in honey bees …

Ribosomes across species contain subsets of zinc finger proteins that play structural roles
by binding to rRNA. While the majority of these zinc fingers belong to the C2-C2 type, the …

Programmable genome editors are enzymes that can be targeted to a specific location in the
genome for making site-specific alterations or deletions. The engineering, design, and …