Multiple genetic and environmental factors have been associated with an increased risk for
rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation.
The presence of autoantibodies in the sera of RA patients has provided many clues to the …

The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for
mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity …

Immune cells constantly patrol the body via the bloodstream and migrate into multiple
tissues where they face variable and sometimes demanding environmental conditions …

Altered tryptophan catabolism has been identified in inflammatory diseases like rheumatoid
arthritis (RA) and spondyloarthritis (SpA), but the causal mechanisms linking tryptophan …

Increased protein citrullination is linked to various diseases including rheumatoid arthritis
(RA), lupus, and cancer. Citrullinated autoantigens, a hallmark of RA, are recognized by anti …

Activation of endothelium and immune cells is fundamental to the initiation of autoimmune
diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration …

Rheumatoid arthritis (RA) is an autoimmune disease characterized in seropositive
individuals by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked …

Rheumatoid arthritis (RA) is a potentially devastating autoimmune disease. The great
majority of patients with RA are seropositive for anti-citrullinated protein antibodies (ACPAs) …

Purpose This article reviews the phases of rheumatoid arthritis (RA) development in terms of
the evolution of disease, with a focus on events that occur before the first appearance of …