Antimicrobial resistance is a major obstacle for the treatment of infectious diseases and
currently represents one of the most significant threats to global health. Staphylococcus …

Bacterial antibiotic resistance, especially the emergence of multidrug-resistant (MDR)
strains, urgently requires the development of effective treatment strategies. It is always of …

Background Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the
effect of the microbiome on uric acid (UA) metabolism remains unclear. This study aimed to …

Central metabolic pathways control virulence and antibiotic resistance, and constitute
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …

Streptococcus pneumoniae is a major human pathogen and rising resistance to β-lactam
antibiotics, such as penicillin, is a significant threat to global public health. Mutations …

Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is a common
bacterial infection that is a significant source of illness and mortality globally. The …

The stringent response and its signalling nucleotides, pppGpp and ppGpp, have been the
subject of intense research since the discovery of (p) ppGpp in 1969. Recent studies have …

Cyclic di-guanosine monophosphate (c-di-GMP) is a bacterial second messenger that
governs the lifestyle switch between planktonic and biofilm states. While substantial …

The ability of pathogenic bacteria to evade antibiotic treatment is an intricate and
multifaceted phenomenon. Over the years, treatment failure among patients due to …

There is increasing interest in the antimicrobial activity of mannosylerythritol lipids-B (MEL-
B) against Gram-positive bacteria such as Staphylococcus aureus (S. aureus). However, the …