Following the sequencing of the human genome and many other organisms, research on
protein-coding genes and their functions (functional genomics) has intensified …

The 78-kDa glucose-regulated protein (GRP78) plays an important part in maintaining
protein stability, regulating protein folding, and inducing apoptosis autophagy, which is …

This article presents an overview of the literature and a review of recent advances in the
analysis of stable and transient protein–protein interactions (PPI s) with a focus on their …

Liver infection with hepatitis B virus (HBV), a DNA virus of the Hepadnaviridae family, leads
to severe disease, such as fibrosis, cirrhosis and hepatocellular carcinoma. The early steps …

Multidrug resistance (MDR) remains a significant challenge to the clinical treatment of
gastric cancer (GC). In the present study, using a phage display approach combined with …

Vascular integrity and the maintenance of blood vessel continuity are fundamental features
of the circulatory system maintained through endothelial cell–cell junctions. Defects in the …

The endoplasmic reticulum chaperone BiP (also known as GRP-78 or HSPA5) maintains
protein folding to allow cell proliferation and survival and has been implicated in …

Extracellular matrix stiffness (ECM) is one of the many mechanical forces acting on
mammalian adherent cells and an important determinant of cellular function. While the effect …

The combination of SDS‐PAGE and MS is one of the most powerful and perhaps most
frequently used gel‐based proteomics approaches in protein identification. However, one …

Biomarkers are greatly needed in the fields of neurology and psychiatry, to provide objective
and earlier diagnoses of CNS conditions. Proteomics and other omics MS‐based …