This review describes the recent advances made in difluoromethylation processes based on
X–CF2H bond formation where X is C (sp), C (sp2), C (sp3), O, N or S, a field of research …

Halodifluoromethyl and trifluoromethyl-containing compounds are widely employed in
organic chemistry, pharmaceuticals and materials science. Therefore, their applications and …

The first efficient access to N-difluoromethyl amides, carbamates, thiocarbamates, ureas,
formamides, and their derivatives is reported herein. The synthetic strategy relies on the …

Recent years have witnessed a growing interest in the development of novel synthetic
methods and new reagents for the synthesis of difluoromethylated compounds. Dozens of …

A protocol for the modular assembly of the α‐fluoroamide motif has been developed, which
provides a practical method for the efficient synthesis of structurally diverse α‐fluoroamides …

Various primary amides have been synthesized using the transamidation of various tertiary
amides under metal-free and mild reaction conditions. When (NH4) 2CO3 reacts with a …

Here we present a novel annulation of pyridinium salts with BrCF2CO2Et to access the
indolizine derivatives with high efficiency. The α substitution of pyridine plays a key role in …

A strategy utilizing silver-catalyzed oxidative decarboxylation radical cascade cyclization of
arylthiodifluoroacetic acids with alkenes for the simple and efficient preparation of …

The heptafluoroisopropyl group (CF (CF3) 2) is prevalent in pharmaceuticals and
agrichemicals. However, heptafluoroisopropoxylated (OCF (CF3) 2) compounds remain …

Abstract N‐(difluoromethyl) amino (− NCF2H) compounds are of great interest given their
unique and underexplored physiochemical properties. The lack of structural diversity in …