The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Autotaxin (ATX) is a secreted glycoprotein and functions as a key enzyme to produce
extracellular lysophosphatidic acid (LPA). LPA interacts with at least six G protein-coupled …

First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …

Autotaxin (ATX) is a member of the ectonucleotide pyrophosphate/phosphodiesterase
(ENPP) family; it is encoded by the ENPP2 gene. ATX is a secreted glycoprotein and …

Although simple in structure, lysophosphatidic acid (LPA) is a potent bioactive lipid that
profoundly influences cellular signaling and function upon binding to G protein-coupled …

The global incidence of obesity has led to an increasing need for understanding the
molecular mechanisms that drive this epidemic and its comorbidities. Quantitative real-time …

A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-
lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical …

Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid
(LPA). ATX-LPA signaling has been implicated in diet-induced obesity and systemic insulin …

Background Disorders of lipid metabolism are critical factors in the progression of chronic
lymphocytic leukemia (CLL). However, the characteristics of lipid metabolism and related …

After a decade of intense preclinical investigations, the first in-class autotaxin inhibitor,
GLPG1690, has entered Phase III clinical trials for idiopathic pulmonary fibrosis. In the …