Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

Significant advances in materials, microscale technology, and stem cell biology have
enabled the construction of 3D tissues and organs, which will ultimately lead to more …

To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …

The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …

After several billions of years, nature still makes decisions on its own to identify, develop,
and direct the most effective material for phenomena/challenges faced. Likewise, and …

“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and
biomimetic principles to create key aspects of living organs faithfully, including critical …

Organ-on-a-chip technology can simulate the physiological and pathological
microenvironment of tissues and organs in vitro, thus offering the potential of dispensing with …

Cilia are microscopic hair-like external cell organelles that are ubiquitously present in
nature, also within the human body. They fulfill crucial biological functions: motile cilia …

Diabetic nephropathy is a major chronic renal complication of diabetes mellitus, and is the
leading cause of end-stage kidney diseases. Establishing a disease model of diabetic …

Introduction: The development of emerging in vitro tissue culture platforms can be useful for
predicting human response to new compounds, which has been traditionally challenging in …