Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Ubiquitination is an important post-translational modification (PTM) for protein substrates,
whereby ubiquitin is added to proteins through the coordinated activity of activating (E1) …

Background Skeletal muscle mass and strength diminish during periods of disuse but
recover upon return to weight bearing in healthy adults but are incomplete in old muscle …

Healthy brain activity requires precise ion and energy management creating a strong
reliance on mitochondrial function. Age-related neurodegeneration leads to a decline in …

This Special Issue presents some of the most recent studies on the skeletal muscle
denervation. Skeletal muscle innervation comprises stable and functional nerve interactions …

SIRT3 is a longevity factor that acts as the primary deacetylase in mitochondria. Although
ubiquitously expressed, previous global SIRT3 knockout studies have shown primarily a …

Skeletal muscle size is controlled by the balance between protein synthesis and protein
degradation. Given the essential role of skeletal muscle in maintaining a high quality of life …

Cardiovasomobility is a novel concept that encompasses the integration of cardiovascular
and skeletal muscle function in health and disease with critical modification by physical …

High‐fat diet (HFD) and exercise remodel skeletal muscle mitochondria. The electron
transfer flavoproteins (ETF) transfer reducing equivalents from β‐oxidation into the electron …

Right heart failure (RHF) is a common and deadly disease in aged populations. Extra-
cardiac outcomes of RHF such as skeletal muscle atrophy contribute to morbidity and …