The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification
Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development
S Oda, T Fukami, T Yokoi, M Nakajima - Drug metabolism and …, 2015 - Elsevier
UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …
non-P450 enzymes because of their high contribution to drug metabolism. UGTs catalyze …
Renal drug metabolism in humans: the potential for drug–endobiotic interactions involving cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT)
KM Knights, A Rowland… - British journal of clinical …, 2013 - Wiley Online Library
Although knowledge of human renal cytochrome P450 (CYP) and UDP‐
glucuronosyltransferase (UGT) enzymes and their role in xenobiotic and endobiotic …
glucuronosyltransferase (UGT) enzymes and their role in xenobiotic and endobiotic …
Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and …
Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …
activities represent both a clinical problem and a potential economic loss for the …
The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping …
JO Miners, PI Mackenzie, KM Knights - Drug metabolism reviews, 2010 - Taylor & Francis
Major advances in the characterization of uridine diphosphate (UDP)-
glucuronosyltransferase (UGT) enzyme substrate and inhibitor selectivities and the …
glucuronosyltransferase (UGT) enzyme substrate and inhibitor selectivities and the …
In vitro drug metabolism using liver microsomes
KM Knights, DM Stresser, JO Miners… - Current protocols in …, 2016 - Wiley Online Library
Abstract Knowledge of the metabolic stability of newly discovered drug candidates
eliminated by metabolism is essential for predicting the pharmacokinetic (PK) parameters …
eliminated by metabolism is essential for predicting the pharmacokinetic (PK) parameters …
Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development
M Chiba, Y Ishii, Y Sugiyama - The AAPS journal, 2009 - Springer
The in vivo metabolic clearance in human has been successfully predicted by using in vitro
data of metabolic stability in cryopreserved preparations of human hepatocytes. In the …
data of metabolic stability in cryopreserved preparations of human hepatocytes. In the …
UDP-glucuronosyltransferases (UGTs) and their related metabolic cross-talk with internal homeostasis: A systematic review of UGT isoforms for precision medicine
UDP-glucuronosyltransferases (UGTs) are the primary phase II enzymes catalyzing the
conjugation of glucuronic acid to the xenobiotics with polar groups for facilitating their …
conjugation of glucuronic acid to the xenobiotics with polar groups for facilitating their …
[引用][C] Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin …
PJ Kilford, R Stringer, B Sohal, JB Houston… - Drug Metabolism and …, 2009 - ASPET