Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …

About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Malignant cardiac arrhythmias which result in sudden cardiac death may be present in
individuals apparently healthy or be associated with other medical conditions. The way to …

Collectively, the completion of the Human Genome Project and subsequent development of
high-throughput next-generation sequencing methodologies have revolutionized genomic …

Brugada syndrome is a rare, inherited cardiac disease leading to ventricular fibrillation and
sudden cardiac death in structurally normal hearts. Clinical diagnosis requires a Brugada …

Patient‐specific induced pluripotent stem cells (iPSCs) will assist research on genetic
cardiac maladies if the disease phenotype is recapitulated in vitro. However, genetic …

Congenital long QT syndrome (LQTS) is a genetically heterogeneous group of heritable
disorders of myocardial repolarization linked by the shared clinical phenotype of QT …

Objectives: This study aimed to identify the genetic defect in a family with idiopathic
ventricular fibrillation (IVF) manifesting in childhood and adolescence. Background …

Abstract In 1992, the Brugada syndrome (BrS) was recognized as a disease responsible for
sudden cardiac death, characterized by a right bundle-branch block with ST segment …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …