Our understanding of the process of autophagy and its role in health and diseases has
grown remarkably in the last two decades. Early work established autophagy as a general …

Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules
active in the nucleus and minimizing off-target effects.'Active'nuclear-directed transport and …

The incorporation of light-responsive domains into engineered proteins has enabled control
of protein localization, interactions and function with light. We integrated optogenetic control …

INTRODUCTION In response to many types of stress, eukaryotic cells initiate an adaptive
and reversible response that includes down-regulation of key cellular activities along with …

Ionizing radiation, but not stimulation with epidermal growth factor (EGF), triggers EGF
receptor (EGFR) import into the nucleus in a probably karyopherin α-linked manner. An …

Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular
mechanisms underlying nuclear transport that involve the nuclear transport receptor, small …

We have previously reported that mutations in the polymerase proteins PB1, PB2, PA, and
the nucleocapsid protein NP resulting in enhanced transcription and replication activities in …

The thioredoxin-interacting protein TXNIP is a ubiquitously expressed redox protein that
promotes apoptosis. Recently, we found that TXNIP deficiency protects against type 1 and 2 …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF6 is an antagonist of
interferon (IFN)-mediated antiviral signaling, achieved through the prevention of STAT1 …

Importin α performs the indispensable role of ferrying proteins from the cytoplasm into the
nucleus with a transport carrier, importin β1. Mammalian cells from mouse or human contain …