Therapeutic approaches for Duchenne muscular dystrophy

TC Roberts, MJA Wood, KE Davies - Nature Reviews Drug Discovery, 2023 - nature.com
Duchenne muscular dystrophy (DMD) is a monogenic muscle-wasting disorder and a
priority candidate for molecular and cellular therapeutics. Although rare, it is the most …

Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

[HTML][HTML] Ischemia/reperfusion

T Kalogeris, CP Baines, M Krenz… - Comprehensive …, 2016 - ncbi.nlm.nih.gov
Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Cell biology of ischemia/reperfusion injury

T Kalogeris, CP Baines, M Krenz, RJ Korthuis - International review of cell …, 2012 - Elsevier
Disorders characterized by ischemia/reperfusion (I/R), such as myocardial infarction, stroke,
and peripheral vascular disease, continue to be among the most frequent causes of …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

Analysis of circulating microRNA: preanalytical and analytical challenges

JS McDonald, D Milosevic, HV Reddi… - Clinical …, 2011 - academic.oup.com
BACKGROUND There is great interest in circulating microRNAs (miRNAs) as disease
biomarkers. Translating promising miRNAs into validated clinical tests requires the …

Circulating microRNAs are new and sensitive biomarkers of myocardial infarction

Y D'alessandra, P Devanna, F Limana… - European heart …, 2010 - academic.oup.com
Abstract Aims Circulating microRNAs (miRNAs) may represent a novel class of biomarkers;
therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma …

[HTML][HTML] Myotonic dystrophies: an update on clinical aspects, genetic, pathology, and molecular pathomechanisms

G Meola, R Cardani - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
Myotonic dystrophy (DM) is the most common adult muscular dystrophy, characterized by
autosomal dominant progressive myopathy, myotonia and multiorgan involvement. To date …

Adipose-derived stem cells induce angiogenesis via microvesicle transport of miRNA-31

T Kang, TM Jones, C Naddell… - Stem cells …, 2016 - academic.oup.com
Cell secretion is an important mechanism for stem cell-based therapeutic angiogenesis,
along with cell differentiation to vascular endothelial cells or smooth muscle cells. Cell …

Long noncoding RNA dysregulation in ischemic heart failure

S Greco, G Zaccagnini, A Perfetti, P Fuschi… - Journal of translational …, 2016 - Springer
Abstract Background Long noncoding RNAs (lncRNAs) are non-protein coding transcripts
regulating a variety of physiological and pathological functions. However, their implication in …