We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

The extracellular matrix (ECM) is a key regulator of cell and tissue function. Traditionally, the
ECM has been thought of primarily as a physical scaffold that binds cells and tissues …

Kjær, Michael. Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to
Mechanical Loading. Physiol Rev 84: 649–698, 2004; 10.1152/physrev. 00031.2003.—The …

Tendons connect muscles to bones, ensuring joint movement. With advanced age, tendons
become more prone to degeneration followed by injuries. Tendon repair often requires …

Collagens are triple helical proteins that occur in the extracellular matrix (ECM) and at the
cell–ECM interface. There are more than 30 collagens and collagen-related proteins but the …

Small leucine‐rich proteoglycans (SLRP s) are involved in a variety of biological and
pathological processes. This review focuses on their regulatory roles in matrix assembly …

This article is one of a series, summarizing views expressed at the Orthopaedic Research
Society New Frontiers in Tendon Research Conference. This particular article reviews the …

Conventional chemotherapy, one of the most widely used cancer treatment methods, has
serious side effects, and usually results in cancer treatment failure. Drug resistance is one of …

Osteogenesis imperfecta (OI) is a generalized disorder of connective tissue characterized by
fragile bones and easy susceptibility to fracture. Most cases of OI are caused by mutations in …

The most damaging change during cancer progression is the switch from a locally growing
tumour to a metastatic killer. This switch is believed to involve numerous alterations that …