Motivation: The sequencing of the human genome has made it possible to identify an
informative set of> 1 million single nucleotide polymorphisms (SNPs) across the genome …

The widespread availability of high-throughput genotyping technology has opened the door
to the era of personal genetics, which brings to consumers the promise of using genetic …

Multifactor dimensionality reduction (MDR) was developed as a method for detecting
statistical patterns of epistasis. The overall goal of MDR is to change the representation …

Currently, single-nucleotide polymorphisms (SNPs) with minor allele frequency (MAF) of>
5% are preferentially used in case-control association studies of common human diseases …

Complex interactions among genes and environmental factors are known to play a role in
common human disease aetiology. There is a growing body of evidence to suggest that …

Alzheimer's disease is the most common form of dementia and is the only top 10 cause of
death in the United States that lacks disease‐altering treatments. It is a complex disorder …

Empirical evidence supporting the commonality of gene× gene interactions, coupled with
frequent failure to replicate results from previous association studies, has prompted …

Background: Bladder cancer is one of the most common cancers worldwide. Gene
expression profiling usingmicroarray technologies improves the understanding of cancer …

Background Epistasis is recognized ubiquitous in the genetic architecture of complex traits
such as disease susceptibility. Experimental studies in model organisms have revealed …

Bladder cancer is the fourth most common malignancy in men and the eighth most common
in women in western countries. Single nucleotide polymorphisms (SNPs) in genes that …