Strecker reaction and α-amino nitriles: Recent advances in their chemistry, synthesis, and biological properties

VV Kouznetsov, CEP Galvis - Tetrahedron, 2018 - Elsevier
Abstract α-Amino nitrile compounds have a profound impact on bio-chemical sciences, as
they have been prepared from inexpensive starting materials and have become valuable …

Recent advances in electrochemical synthesis of nitriles: a sustainable approach

RM Rodrigues, DA Thadathil, K Ponmudi… - …, 2022 - Wiley Online Library
Nitriles unveil widespread applications in pharmaceuticals, agrochemicals, textiles, rubber,
polymers, and constitute a significant intermediate in several organic transformations …

Advances in C–CN bond formation via C–H bond activation

Y Ping, Q Ding, Y Peng - ACS Catalysis, 2016 - ACS Publications
The cyano group is well known as a versatile intermediate for transformations into a
multitude of useful functional groups such as carboxyl, carbamoyl, aminomethyl, carbonyl …

Room temperature decarboxylative cyanation of carboxylic acids using photoredox catalysis and cyanobenziodoxolones: a divergent mechanism compared to …

F Le Vaillant, MD Wodrich, J Waser - Chemical science, 2017 - pubs.rsc.org
The one-step conversion of aliphatic carboxylic acids to the corresponding nitriles has been
accomplished via the merger of visible light mediated photoredox and …

Iridium‐Catalyzed Reductive Strecker Reaction for Late‐Stage Amide and Lactam Cyanation

ÁL Fuentes de Arriba, E Lenci… - Angewandte Chemie …, 2017 - Wiley Online Library
A new iridium‐catalyzed reductive Strecker reaction for the direct and efficient formation of α‐
amino nitrile products from a broad range of (hetero) aromatic and aliphatic tertiary amides …

C–H bond functionalization of amines: a graphical overview of diverse methods

S Dutta, B Li, DRL Rickertsen, DA Valles, D Seidel - SynOpen, 2021 - thieme-connect.com
Thieme E-Journals - SynOpen / Full Text DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SynOpen Full-text search Full-text search Author …

Organocatalytic synthesis of α-aminonitriles: a review

B Ullah, NK Gupta, Q Ke, N Ullah, X Cai, D Liu - Catalysts, 2022 - mdpi.com
α-Aminonitriles, which have anticancer, antibacterial, antiviral, and antifungal properties,
have played an important role in pharmacology. Furthermore, they can also be used to …

Synthesis of polycyclic cyclohexadienone through alkoxy-oxylactonization and dearomatization of 3′-hydroxy-[1, 1′-biphenyl]-2-carboxylic acids promoted by …

Q Deng, W Xia, MI Hussain, X Zhang… - The Journal of …, 2020 - ACS Publications
Alkox-oxylactonization and dearomatization of 3′-hydroxy-[1, 1′-biphenyl]-2-carboxylic
acid simultaneously promoted by hypervalent iodine have been developed using …

PIFA-Promoted, Solvent-Controlled Selective Functionalization of C(sp2)–H or C(sp3)–H: Nitration via C–N Bond Cleavage of CH3NO2, Cyanation, or Oxygenation …

C Mudithanapelli, LP Dhorma, M Kim - Organic letters, 2019 - ACS Publications
A novel nitration (via C (sp3)–N breaking/C (sp2)–N formation with CH3NO2) mediated by
[bis (trifluoroacetoxy) iodo] benzene (PIFA) is described. The NO2 transfer from CH3NO2 to …

Electrochemical 2, 2, 6, 6-tetramethylpiperidinyl-N-oxyl (TEMPO)-mediated α-cyanation and phosphonylation of cyclic amines with metal-free conditions

G Junqing, W Xinjun, M Cong, X Xuetao… - Chinese Journal of …, 2021 - sioc-journal.cn
Metal-free electrochemical oxidation cyanation and phosphonylation reactions had been
developed, in which 2, 2, 6, 6-tetramethylpiperidinyl-N-oxyl (TEMPO) reduced the electrode …