Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of
Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins
(RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to …

Differences in immune responses to viruses and autoimmune diseases such as systemic
lupus erythematosus (SLE) can show sexual dimorphism. Age-associated B cells (ABC) are …

Age‐associated B cells (ABCs) have emerged as critical components of immune responses.
Their inappropriate expansion and differentiation have increasingly been linked to the …

ROP GTPases Structure-Function and Signaling Pathways | Plant Physiology | Oxford
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Mammalian Dock180 and ELMO proteins, and their homologues in Caenorhabditis elegans
and Drosophila melanogaster, function as critical upstream regulators of Rac during …

To determine the site and mechanism of suppression by regulatory T (Treg) cells, we
investigated their migration and function in an islet allograft model. Treg cells first migrated …

The induction of alloantigen-specific unresponsiveness remains an elusive goal in organ
transplantation. Here we identify plasmacytoid dendritic cells (pDCs) as phagocytic antigen …

The plasma membrane of many motile cells undergoes highly regulated protrusions and
invaginations that support the formation of podosomes, invadopodia and circular dorsal …