Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Misfolded Cu, Zn-
superoxide dismutase (SOD1) has been linked to both familial and sporadic ALS. SOD1 …

Aberrant accumulation of misfolded Cu, Zn superoxide dismutase (SOD1) is a hallmark of
SOD1-associated amyotrophic lateral sclerosis (ALS), an invariably fatal neurodegenerative …

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of the
motor neurons that innervate muscle, resulting in gradual paralysis and culminating in the …

Protein misfolding and amyloid formation are hallmarks of numerous diseases, including
amyotrophic lateral sclerosis (ALS), in which hSOD1 aggregation is involved in …

The formation of superoxide dismutase 1 (SOD1) filaments has been implicated in
amyotrophic lateral sclerosis (ALS). Although the disulfide bond formed between Cys57 and …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and is characterized by
degeneration and axon loss from the upper motor neuron, that descends from the lower …

It is rare for one fluorophore scaffold to harbor both positive and negative solvatochromism.
Herein, we tailor chalcone analogues to achieve both positive-and negative-polarity …

SOD1 misfolding, toxic gain of function, and spread are proposed as a pathological basis of
amyotrophic lateral sclerosis (ALS), but the nature of SOD1 toxicity has been difficult to …