Corticotropin releasing factor: a key role in the neurobiology of addiction
Drug addiction is a chronically relapsing disorder characterized by loss of control over intake
and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie …
and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie …
The role of CRF and CRF-related peptides in the dark side of addiction
GF Koob - Brain research, 2010 - Elsevier
Drug addiction is a chronically relapsing disorder characterized by a compulsion to seek
and take drugs, the development of dependence, and the manifestation of a negative …
and take drugs, the development of dependence, and the manifestation of a negative …
Peptidergic and functional delineation of the Edinger-Westphal nucleus
Many neuronal populations that release fast-acting excitatory and inhibitory
neurotransmitters in the brain also contain slower-acting neuropeptides. These facultative …
neurotransmitters in the brain also contain slower-acting neuropeptides. These facultative …
The Edinger‐Westphal nucleus: A historical, structural, and functional perspective on a dichotomous terminology
T Kozicz, JC Bittencourt, PJ May… - Journal of …, 2011 - Wiley Online Library
The eponymous term nucleus of Edinger‐Westphal (EW) has come to be used to describe
two juxtaposed and somewhat intermingled cell groups of the midbrain that differ …
two juxtaposed and somewhat intermingled cell groups of the midbrain that differ …
Ghrelin receptor antagonism decreases alcohol consumption and activation of perioculomotor urocortin‐containing neurons
S Kaur, AE Ryabinin - Alcoholism: Clinical and Experimental …, 2010 - Wiley Online Library
Background: The current therapies for alcohol abuse disorders are not effective in all
patients, and continued development of pharmacotherapies is needed. One approach that …
patients, and continued development of pharmacotherapies is needed. One approach that …
Stress-related neuropeptides and addictive behaviors: beyond the usual suspects
Addictive disorders are chronic, relapsing conditions that cause extensive disease burden.
Genetic factors partly account for susceptibility to addiction, but environmental factors such …
Genetic factors partly account for susceptibility to addiction, but environmental factors such …
Sex-specific differences in the dynamics of cocaine-and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs …
B Bloem, L Xu, É Morava, G Faludi, M Palkovits… - …, 2012 - Elsevier
An intriguing novel pathophysiological insight into mood disorders is the notion that one's
metabolic status influences mood. In rodents, cocaine-and amphetamine-regulated …
metabolic status influences mood. In rodents, cocaine-and amphetamine-regulated …
Restraint stress alters the secretory activity of neurons co-expressing urocortin-1, cocaine-and amphetamine-regulated transcript peptide and nesfatin-1 in the mouse …
Central stress regulatory pathways utilize various neuropeptides, such as urocortin-1 (Ucn1)
and cocaine-and amphetamine-regulated transcript peptide (CART). Ucn1 is most …
and cocaine-and amphetamine-regulated transcript peptide (CART). Ucn1 is most …
Stress-related changes in the activity of cocaine-and amphetamine-regulated transcript and nesfatin neurons in the midbrain non-preganglionic Edinger–Westphal …
Cocaine-and amphetamine-regulated transcript (CART) and nesfatin-1/nucleobindin 2
(NUCB2) are assumed to play a role in feeding and adaptation to stress. Both peptides are …
(NUCB2) are assumed to play a role in feeding and adaptation to stress. Both peptides are …
Urocortins: CRF's siblings and their potential role in anxiety, depression and alcohol drinking behavior
It is widely accepted that stress, anxiety, depression and alcohol abuse-related disorders are
in large part controlled by corticotropin-releasing factor (CRF) receptors. However, evidence …
in large part controlled by corticotropin-releasing factor (CRF) receptors. However, evidence …