Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents
In connection with our research program on the development of novel anti-tubercular
candidates, herein we report the design and synthesis of two different sets of indole …
candidates, herein we report the design and synthesis of two different sets of indole …
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective …
The synthesis and characterization of two new sets of arylsulfonehydrazone
benzenesulfonamides (4a-4i with phenyl tail and 4j-4q with tolyl tail) are reported. The …
benzenesulfonamides (4a-4i with phenyl tail and 4j-4q with tolyl tail) are reported. The …
Anti-inflammatory and antialgic actions of a nanoemulsion of Rosmarinus officinalis L. essential oil and a molecular docking study of its major chemical constituents
We evaluate the anti-inflammatory and antialgic potency of a nanoemulsion (NEORO)
containing the essential oil of Rosmarinus officinalis L.(EORO), which is composed primarily …
containing the essential oil of Rosmarinus officinalis L.(EORO), which is composed primarily …
Discovery of potent dual-tailed benzenesulfonamide inhibitors of human carbonic anhydrases implicated in glaucoma and in vivo profiling of their intraocular pressure …
The design of three dual-tailed sulfonamide series 11a–11g, 14a–14h, and 16a–16e as
carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors are presented. All compounds were …
carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors are presented. All compounds were …
Novel Thiazolidinone/Thiazolo[3,2-a]Benzimidazolone-Isatin Conjugates as Apoptotic Anti-proliferative Agents Towards Breast Cancer: One-Pot Synthesis and In …
In connection with our research program on the development of new isatin-based anticancer
candidates, herein we report the synthesis of two novel series of thiazolidinone-isatin …
candidates, herein we report the synthesis of two novel series of thiazolidinone-isatin …
Novel sulfones with antifungal properties: antifungal activities and interactions with Candida spp. virulence factors
M Gizińska, M Staniszewska… - Mini Reviews in Medicinal …, 2019 - ingentaconnect.com
Since candidiasis is so difficult to eradicate with an antifungal treatment and the existing
antimycotics display many limitations, hopefully new sulfone derivatives may overcome …
antimycotics display many limitations, hopefully new sulfone derivatives may overcome …
Drug design strategies for the treatment azole-resistant candidiasis
S Moghimi, M Shafiei, A Foroumadi - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Despite the availability of novel antifungals and therapeutic strategies, the rate
of global mortality linked to invasive fungal diseases from fungal infection remains high …
of global mortality linked to invasive fungal diseases from fungal infection remains high …
DFT and molecular docking studies of self-assembly of sulfone analogues and graphene
JS Al-Otaibi, AH Almuqrin, YS Mary, YS Mary… - Journal of Molecular …, 2020 - Springer
Detection and qualification process related to impurities assume importance in
pharmacological drug development programs, and the present article gives the structural …
pharmacological drug development programs, and the present article gives the structural …
New N-alkylated heterocyclic compounds as prospective NDM1 inhibitors: Investigation of in vitro and in silico properties
Y Kaddouri, B Bouchal, F Abrigach, M El Kodadi… - Pharmaceuticals, 2022 - mdpi.com
A new family of pyrazole-based compounds (1–15) was synthesized and characterized
using different physicochemical analyses, such as FTIR, UV-Visible, 1H, 13C NMR, and …
using different physicochemical analyses, such as FTIR, UV-Visible, 1H, 13C NMR, and …
Synthesis and biological evaluation of 2-aminothiazole-thiazolidinone conjugates as potential antitubercular agents
Aim: Mycobacterium tuberculosis, which causes tuberculosis, continues to infect millions of
the global population, resulting in 1.8 million deaths worldwide in 2015. Methodology …
the global population, resulting in 1.8 million deaths worldwide in 2015. Methodology …