Oxidation and deamidation of monoclonal antibody products: potential impact on stability, biological activity, and efficacy
The role in human health of therapeutic proteins in general, and monoclonal antibodies
(mAbs) in particular, has been significant and is continuously evolving. A considerable …
(mAbs) in particular, has been significant and is continuously evolving. A considerable …
Instability of therapeutic proteins—An overview of stresses, stabilization mechanisms and analytical techniques involved in Lyophilized proteins
Solid-state is the preferred choice for storage of protein therapeutics to improve stability and
preserve the biological activity by decreasing the physical and chemical degradation …
preserve the biological activity by decreasing the physical and chemical degradation …
Chemical and physical instabilities in manufacturing and storage of therapeutic proteins
ME Krause, E Sahin - Current opinion in biotechnology, 2019 - Elsevier
Highlights•Proteins undergo spontaneous degradation during manufacturing and
storage.•Chemical modifications to proteins can influence physical stability.•Predictive tools …
storage.•Chemical modifications to proteins can influence physical stability.•Predictive tools …
Science and art of protein formulation development
W Wang, S Ohtake - International journal of pharmaceutics, 2019 - Elsevier
Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …
expected to grow steadily over the next decade. Development of a commercial protein …
In silico prediction of post-translational modifications in therapeutic antibodies
S Vatsa - MAbs, 2022 - Taylor & Francis
Monoclonal antibodies are susceptible to chemical and enzymatic modifications during
manufacturing, storage, and shipping. Deamidation, isomerization, and oxidation can …
manufacturing, storage, and shipping. Deamidation, isomerization, and oxidation can …
Machine learning enables accurate prediction of asparagine deamidation probability and rate
The spontaneous conversion of asparagine residues to aspartic acid or iso-aspartic acid, via
deamidation, is a major pathway of protein degradation and is often seriously disruptive to …
deamidation, is a major pathway of protein degradation and is often seriously disruptive to …
A novel method for in silico assessment of Methionine oxidation risk in monoclonal antibodies: Improvement over the 2-shell model
Over the past decade, therapeutic monoclonal antibodies (mAbs) have established their role
as valuable agents in the treatment of various diseases ranging from cancers to infectious …
as valuable agents in the treatment of various diseases ranging from cancers to infectious …
Stability of protein pharmaceuticals: Recent advances
MC Manning, RE Holcomb, RW Payne… - Pharmaceutical …, 2024 - Springer
There have been significant advances in the formulation and stabilization of proteins in the
liquid state over the past years since our previous review. Our mechanistic understanding of …
liquid state over the past years since our previous review. Our mechanistic understanding of …
[HTML][HTML] Engineering stability, viscosity, and immunogenicity of antibodies by computational design
D Kuroda, K Tsumoto - Journal of Pharmaceutical Sciences, 2020 - Elsevier
In recent years, computational methods have garnered much attention in protein
engineering. A large number of computational methods have been developed to analyze the …
engineering. A large number of computational methods have been developed to analyze the …
Prediction of methionine oxidation risk in monoclonal antibodies using a machine learning method
Monoclonal antibodies (mAbs) have become a major class of protein therapeutics that target
a spectrum of diseases ranging from cancers to infectious diseases. Similar to any protein …
a spectrum of diseases ranging from cancers to infectious diseases. Similar to any protein …