[HTML][HTML] Emerging critical roles of Fe–S clusters in DNA replication and repair
Fe–S clusters are partners in the origin of life that predate cells, acetyl-CoA metabolism,
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base …
DNA, and the RNA world. The double helix solved the mystery of DNA replication by base …
Eukaryotic DNA polymerases
R Jain, AK Aggarwal, O Rechkoblit - Current opinion in structural biology, 2018 - Elsevier
Highlights•Humans encode 16 bone-fide DNA polymerases.•Replicative DNA polymerases
are emerging as highly flexible and dynamic in their interactions.•Mutations in replicative …
are emerging as highly flexible and dynamic in their interactions.•Mutations in replicative …
Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases
SA Nick McElhinny, BE Watts… - Proceedings of the …, 2010 - National Acad Sciences
Measurements of nucleoside triphosphate levels in Saccharomyces cerevisiae reveal that
the four rNTPs are in 36-to 190-fold molar excess over their corresponding dNTPs. During …
the four rNTPs are in 36-to 190-fold molar excess over their corresponding dNTPs. During …
Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation
The eukaryotic CMG (Cdc45, Mcm2–7, GINS) helicase consists of the Mcm2–7 hexameric
ring along with five accessory factors. The Mcm2–7 heterohexamer, like other hexameric …
ring along with five accessory factors. The Mcm2–7 heterohexamer, like other hexameric …
CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol ɛ, and GINS in budding yeast
S Muramatsu, K Hirai, YS Tak… - Genes & …, 2010 - genesdev.cshlp.org
Eukaryotic chromosomal DNA replication requires cyclin-dependent kinase (CDK) activity.
CDK phosphorylates two yeast replication proteins, Sld3 and Sld2, both of which bind to …
CDK phosphorylates two yeast replication proteins, Sld3 and Sld2, both of which bind to …
The architecture of a eukaryotic replisome
At the eukaryotic DNA replication fork, it is widely believed that the Cdc45–Mcm2–7–GINS
(CMG) helicase is positioned in front to unwind DNA and that DNA polymerases trail behind …
(CMG) helicase is positioned in front to unwind DNA and that DNA polymerases trail behind …
Arabidopsis DPB3-1, a DREB2A Interactor, Specifically Enhances Heat Stress-Induced Gene Expression by Forming a Heat Stress-Specific Transcriptional Complex …
Abstract DEHYDRATION-RESPONSIVE ELEMENT BINDING PROTEIN2A (DREB2A) is a
key transcription factor for drought and heat stress tolerance in Arabidopsis thaliana …
key transcription factor for drought and heat stress tolerance in Arabidopsis thaliana …
Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ
M Hogg, P Osterman, GO Bylund, RA Ganai… - Nature structural & …, 2014 - nature.com
DNA polymerase ɛ (Pol ɛ) is a high-fidelity polymerase that has been shown to participate
in leading-strand synthesis during DNA replication in eukaryotic cells. We present here a …
in leading-strand synthesis during DNA replication in eukaryotic cells. We present here a …
Eukaryotic DNA polymerase ζ
AV Makarova, PM Burgers - DNA repair, 2015 - Elsevier
This review focuses on eukaryotic DNA polymerase ζ (Pol ζ), the enzyme responsible for the
bulk of mutagenesis in eukaryotic cells in response to DNA damage. Pol ζ is also …
bulk of mutagenesis in eukaryotic cells in response to DNA damage. Pol ζ is also …
Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome
Z Yuan, R Georgescu, GD Schauer… - Nature …, 2020 - nature.com
The eukaryotic leading strand DNA polymerase (Pol) ε contains 4 subunits, Pol2, Dpb2,
Dpb3 and Dpb4. Pol2 is a fusion of two B-family Pols; the N-terminal Pol module is catalytic …
Dpb3 and Dpb4. Pol2 is a fusion of two B-family Pols; the N-terminal Pol module is catalytic …