Progress in 1, 3-dipolar cycloadditions in the recent decade: an update to strategic development towards the arsenal of organic synthesis
The synthetic strategies involving the construction and cleavage of a bond represent the
central theme in organic synthesis. The cleavage of a bond is achieved either by weakening …
central theme in organic synthesis. The cleavage of a bond is achieved either by weakening …
Synthesis of carbocyclic and heterocyclic β-aminocarboxylic acids
In consequence of their biological effects, conformationally constrained carbocyclic β-amino
acids have generated great interest among synthetic and medicinal chemists in the past 2 …
acids have generated great interest among synthetic and medicinal chemists in the past 2 …
Highly functionalized cyclic β-amino acid moieties as promising scaffolds in peptide research and drug design
Peptide-based drug research has received high attention in the field of medicinal chemistry
over the past decade. For drug design, to improve proteolytic stability, it is desirable to …
over the past decade. For drug design, to improve proteolytic stability, it is desirable to …
Nitrile Oxide, Alkenes, Dipolar Cycloaddition, Isomerization and Metathesis Involved in the Syntheses of 2-Isoxazolines
The involvement of 1, 3-dipolar cycloaddition (1, 3-DP), double bond migration, metathesis,
and nitrile oxide (including in situ-generated nitrile oxide) as dipoles, together with the C= C …
and nitrile oxide (including in situ-generated nitrile oxide) as dipoles, together with the C= C …
Synthesis of fluorinated piperidine and azepane β-amino acid derivatives
A convenient and robust stereocontrolled procedure has been developed for the synthesis
of novel trifluoromethyl-containing piperidine and azepane β-amino ester stereoisomers …
of novel trifluoromethyl-containing piperidine and azepane β-amino ester stereoisomers …
Recent progress in the selective fluorinations of some functionalized cycloalkenes
Organofluorine compounds have had an increasing impact in synthetic organic chemistry
and pharmaceutical research over the past two decades. Their syntheses and the …
and pharmaceutical research over the past two decades. Their syntheses and the …
Review of the synthesis of acyclic and cyclic oxime ethers
Oxime ethers have attracted much attention due to their potential biological activities and
wide variety of synthetic applications. Developing more efficient methods for the synthesis of …
wide variety of synthetic applications. Developing more efficient methods for the synthesis of …
Synthesis of fluorinated amino acid derivatives through late-stage deoxyfluorinations
Fluorine chemistry has represented a hot topic in drug research over the last decade.
Because of their pharmaceutical potential, fluorine-containing amino acids and related …
Because of their pharmaceutical potential, fluorine-containing amino acids and related …
[PDF][PDF] A new access route to functionalized cispentacins from norbornene β-amino acids.
The concept of the synthetic route, represented in the retrosynthetic scheme (Scheme 1),
was the functionalization of the CÀC ring double bond of the di-exo-norbornene βlactam by …
was the functionalization of the CÀC ring double bond of the di-exo-norbornene βlactam by …
A stereocontrolled protocol to highly functionalized fluorinated scaffolds through a fluoride opening of oxiranes
A novel selective and substrate-dependent synthetic protocol has been developed towards
the synthesis of various fluorine-containing, highly functionalized cycloalkane derivatives …
the synthesis of various fluorine-containing, highly functionalized cycloalkane derivatives …